Guilherme Baldo Selected Research

Mucopolysaccharidosis I (Hurler Syndrome)

1/2022	Brain and visceral gene editing of mucopolysaccharidosis I mice by nasal delivery of the CRISPR/Cas9 system.
1/2021	Cardiac pathology in mucopolysaccharidosis I mice: Losartan modifies ERK1/2 activation during cardiac remodeling.
3/2020	Mucopolysaccharidosis Type I.
2/2020	Cathepsin B-associated Activation of Amyloidogenic Pathway in Murine Mucopolysaccharidosis Type I Brain Cortex.
1/2020	Neonatal nonviral gene editing with the CRISPR/Cas9 system improves some cardiovascular, respiratory, and bone disease features of the mucopolysaccharidosis I phenotype in mice.
1/2020	Progressive eye pathology in mucopolysaccharidosis type I mice and effects of enzyme replacement therapy.
12/2018	CRISPR-Cas9-mediated gene editing in human MPS I fibroblasts.
10/2018	In vivo genome editing of mucopolysaccharidosis I mice using the CRISPR/Cas9 system.
10/2018	Comment on "report of 5 novel mutations of the α-L-iduronidase gene and comparison of Korean mutations in relation with those of Japan or China in patients with mucopolysaccharidosis I".
9/2018	Nasal Administration of Cationic Nanoemulsions as Nucleic Acids Delivery Systems Aiming at Mucopolysaccharidosis Type I Gene Therapy.

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Guilherme Baldo Research Topics

Disease

25	Mucopolysaccharidosis I (Hurler Syndrome) 01/2022 - 05/2010
10	Mucopolysaccharidoses 06/2022 - 07/2012
5	Inborn Genetic Diseases (Disease, Hereditary) 01/2021 - 01/2013
4	Heart Diseases (Heart Disease) 03/2021 - 01/2015
3	Neoplasms (Cancer) 01/2021 - 01/2021
3	Mucopolysaccharidosis II (Hunter Syndrome) 10/2020 - 01/2018
3	Mucopolysaccharidosis VI (Syndrome, Maroteaux-Lamy) 01/2015 - 06/2011
3	Mucopolysaccharidosis VII (Sly Syndrome) 11/2013 - 12/2011
2	Hematologic Diseases (Blood Diseases) 06/2022 - 01/2021
2	Pulmonary Arterial Hypertension 11/2021 - 01/2021
2	Neuroinflammatory Diseases 01/2021 - 01/2021
2	Necrosis 01/2021 - 05/2008
2	Cognitive Dysfunction 03/2020 - 02/2015
2	Mucopolysaccharidosis IV (Morquio Syndrome) 02/2019 - 01/2016
2	Lysosomal Storage Diseases (Lysosomal Storage Disease) 05/2013 - 01/2012
1	Mucopolysaccharidosis III (Sanfilippo Syndrome) 01/2022
1	Disease Progression 11/2021
1	Burns 01/2021
1	Infections 01/2021
1	Maple Syrup Urine Disease 01/2021
1	Wounds and Injuries (Trauma) 01/2021
1	Glutaric Acidemia I 01/2021
1	Amyloid Plaque 02/2020
1	Corneal Opacity 01/2020
1	Eye Diseases (Eye Disease) 01/2020
1	GM1 Gangliosidosis (Gangliosidosis GM1) 09/2019
1	Protein Deficiency 01/2019
1	Neurologic Manifestations (Neurological Manifestations) 01/2018
1	Rare Diseases (Rare Disease) 01/2018
1	Gaucher Disease (Gaucher's Disease) 01/2018
1	B-Cell Lymphoma (Lymphoma, B Cell) 01/2018
1	Hyperglycemia 01/2018
1	Heart Failure 03/2017
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2017
1	Developmental Bone Diseases (Bone Dysplasia) 01/2015
1	Mucolipidoses (Sialidosis) 12/2014
1	Mitral Valve Insufficiency (Mitral Regurgitation) 11/2013
1	Joint Diseases (Joint Disease) 10/2013

Drug/Important Bio-Agent (IBA)

22	GlycosaminoglycansIBA 03/2021 - 12/2011
21	Iduronidase (alpha-L-Iduronidase)IBA 01/2022 - 05/2010
19	EnzymesIBA 01/2022 - 05/2010
5	Proteins (Proteins, Gene)FDA Link 06/2022 - 01/2016
4	Dermatan SulfateIBA 10/2020 - 09/2012
3	Heparitin Sulfate (Heparan Sulfate)IBA 01/2022 - 02/2020
3	Losartan (Cozaar)FDA LinkGeneric 03/2021 - 01/2017
3	CollagenIBA 03/2021 - 10/2013
3	Iduronic Acid (Iduronate)IBA 10/2020 - 06/2011
3	Cathepsin BIBA 02/2020 - 03/2017
3	GlucuronidaseIBA 11/2013 - 12/2011
2	MonocrotalineIBA 11/2021 - 01/2021
1	Busulfan (Busulfex)FDA Link 06/2022
1	Hexosaminidases (Hexosaminidase)IBA 01/2022
1	alpha-N-acetyl-D-glucosaminidase (alpha-N-acetylglucosaminidase)IBA 01/2022
1	ThioredoxinsIBA 11/2021
1	Pharmaceutical PreparationsIBA 03/2021
1	LipidsIBA 03/2021
1	polihexanideIBA 01/2021
1	Carnitine (L-Carnitine)FDA LinkGeneric 01/2021
1	Biocompatible Materials (Biomaterials)IBA 01/2021
1	Anti-Infective Agents (Microbicides)IBA 01/2021
1	Branched-Chain Amino AcidsIBA 01/2021
1	InterleukinsIBA 01/2021
1	Isoleucine (L-Isoleucine)FDA Link 01/2021
1	Leucine (L-Leucine)FDA Link 01/2021
1	Amino Acids FDA Link 01/2021
1	Lysine (L-Lysine)FDA Link 01/2021
1	AcidsIBA 01/2021
1	Propranolol (Inderal)FDA LinkGeneric 01/2021
1	Tryptophan (L-Tryptophan)FDA Link 01/2021
1	Valine (L-Valine)FDA Link 01/2021
1	glutarylcarnitineIBA 01/2021
1	glutaric acidIBA 01/2021
1	Cathepsin DIBA 01/2021
1	Glutaryl-CoA DehydrogenaseIBA 01/2021
1	baysilon (polydimethylsiloxane)IBA 01/2021
1	InflammasomesIBA 10/2020
1	Amyloid (Amyloid Fibrils)IBA 02/2020
1	Retinaldehyde (Retinal)IBA 01/2020
1	GalactosidasesIBA 09/2019
1	Lysergic Acid Diethylamide (LSD)IBA 12/2018
1	Nucleic AcidsIBA 09/2018
1	Streptozocin (Streptozotocin)FDA Link 01/2018
1	JNK Mitogen-Activated Protein KinasesIBA 01/2018
1	p38 Mitogen-Activated Protein KinasesIBA 01/2018
1	Glycogen Synthase (Synthase I)IBA 01/2018
1	Insulin (Novolin)FDA Link 01/2018
1	bcl-2-Associated X Protein (bcl 2 Associated X Protein)IBA 01/2018
1	Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA 01/2018
1	ProteomeIBA 02/2015
1	DNA (Deoxyribonucleic Acid)IBA 12/2014
1	ArylsulfatasesIBA 09/2014
1	Peptide Hydrolases (Proteases)FDA Link 10/2013
1	Proteoglycans (Proteoglycan)IBA 10/2013
1	Chloramphenicol (Chloromycetin)FDA Link 01/2013
1	ChondroitinIBA 09/2012

Therapy/Procedure

9	Therapeutics 11/2021 - 10/2013
7	Enzyme Replacement Therapy 03/2021 - 05/2013
1	Operative Surgical Procedures 01/2021
1	Hematopoietic Stem Cell Transplantation 01/2021
1	Intranasal Administration 09/2018